Magnesium is essential to over 300 biochemical processes in the body- but most people don’t get enough from diet alone.
Magnesium supplements are widely popular, but the majority of people are using cheap forms of magnesium such as Citrate, Oxide or Chloride, which don’t absorb well and are mostly excreted and ineffectively utilized by the central nervous system.
But Magnesium Glycinate is different- it’s in a league of its own when it comes to absorption rate and systemic benefits.
So, what is Magnesium Glycinate?
Magnesium Glycinate is the mineral, magnesium, bound with the amino acid, glycine. Glycine is a powerhouse amino acid, and it’s also an inhibitory neurotransmitter.
As an inhibitory neurotransmitter, glycine helps to calm and soothe the brain and nervous system, reducing overstimulation, stress, and restlessness.
When the mineral magnesium is bonded to the amino acid Glycine, Magnesium Glycinate is created, providing a highly bioavailable magnesium supplement with the added calming benefits of Glycine.
While more expensive than other forms of magnesium, Magnesium Glycinate delivers benefits you can actually feel, even at lower doses.
Magnesium Glycinate Benefits & References
Stress Support
Magnesium glycinate plays a critical role in regulating the body’s stress response system, particularly the hypothalamic-pituitary-adrenal (HPA) axis.
It has been shown to help reduce cortisol levels and support parasympathetic nervous system activity, promoting a state of relaxation.
Glycine itself acts as an inhibitory neurotransmitter, further enhancing the calming effect.
Deep, Restful Sleep
Magnesium is a cofactor in the synthesis of melatonin, the hormone that governs circadian rhythm and sleep onset.
Supplementing with magnesium glycinate helps regulate the body’s internal clock, improve sleep latency (time to fall asleep), and increase time spent in slow-wave and REM sleep- crucial phases for physical recovery and memory consolidation.
Muscle Recovery & Cramp Relief
Magnesium is essential for neuromuscular transmission and muscle relaxation. Deficiency can lead to increased nerve excitability, involuntary contractions, muscle cramps, delayed soreness, and slower muscle recovery.
Magnesium glycinate supports healthy calcium and potassium transport across cell membranes, reducing the risk of cramping and promoting faster recovery from exercise-induced muscle fatigue.
Brain & Mood Boost
Magnesium influences numerous aspects of central nervous system function, including neurotransmitter activity, synaptic plasticity, and neuroinflammation modulation.
Low magnesium levels have been associated with increased incidence of depression and anxiety.
Magnesium glycinate, due to its high bioavailability and calming glycine component, supports GABAergic activity- contributing to mood stability, enhanced focus, and reduced mental fatigue.
Magnesium Glycinate, one of the key ingredients in our REM+ formula, is a foundational mineral that supports deep sleep, a balanced mood, muscle recovery, and a calmer nervous system.
However, the real magic happens when it’s combined with other science-backed ingredients that work synergistically to enhance recovery, mood regulation, and circadian rhythm.
Other REM+ Ingredients include:
Relissa Lemon Balm
A soothing botanical clinically proven to promote relaxation and improve sleep quality.
Affron® Saffron Extract
Clinically backed to support natural serotonin and melatonin production, reduce cortisol, and enhance deep and REM sleep cycles.
Q-Shield® L. plantarum
A gut-brain axis probiotic that supports neurotransmitter health, digestion, immunity, longevity, athletic performance, and recovery
Together, these ingredients form a synergistic solution designed not just to help you fall asleep, but to help you recover, rebuild, and wake up each day with more energy and a healthier gut.
References:
- Wienecke E et al. (2025). Efficacy and safety of magnesium bisglycinate in adults with poor sleep quality: A randomized, double-blind, placebo-controlled trial. Nature and Science of Sleep (Dove Medical Press).
- Supakatisant C, Phupong V. (2015). The efficacy of magnesium bisglycinate chelate for the treatment of pregnancy-associated leg cramps: A randomized controlled trial. Maternal and Child Health Journal.
- de Oliveira EP et al. (2012). Effects of oral magnesium supplementation on physical performance and respiratory muscle function in children and adolescents with cystic fibrosis: A double-blind randomized controlled trial. American Journal of Clinical Nutrition.
- Gröber U et al. (2024). Comparative bioavailability and gastrointestinal tolerability of different magnesium formulations: A double-blind, crossover clinical trial. Nutrients (MDPI).
