REM+ features patented and clinically proven ingredients, all designed to support deep restorative sleep, regulate stress, and support a healthier gut-brain connection*. I recommend it to patients because this unique combination of ingredients plays a crucial role in calming the nervous system and supporting gut health, which is the foundation of recovery and longevity.

Chronically poor sleep quality accelerates biological aging by disrupting hormone balance, increasing inflammation, and impairing cellular repair. REM+ helps prevent this by enhancing REM (Rapid Eye Movement) and deep sleep cycles, reducing nighttime cortisol spikes, improving microbiome health, and restoring circadian rhythm—all of which contribute to slowing “inflammaging” and supporting long-term neurological, metabolic, and immune function.

Definitely. Quality sleep is the foundation for growth hormone release, muscle repair, testosterone regulation, and metabolic function. REM+ helps optimize this nocturnal recovery window by extending deep and REM sleep phases. Additionally, saffron and lemon balm have been linked to reduced cortisol and improved HPA-axis balance—key for athletic performance and recovery.

Great question. REM+ uses magnesium glycinate, a highly absorbable form that is chelated to the amino acid Glycine, which is highly effective at calming the nervous system. What sets REM+ apart is its synergistic formulation—magnesium alone doesn’t have the capacity to positively affect microbiome health, or serotonin/melatonin regulation. The inclusion of Affron® saffron and Relissa® lemon balm works on neurotransmitters and sleep latency, while L. plantarum supports the gut-brain axis, which is critical for building a healthier circadian rhythm and controlling inflammation.

Yes—absolutely. Many of my patients take REM+ for stress regulation, even beyond sleep concerns. The combination of lemon balm (Relissa™ is clinically shown to reduce anxiety symptoms), saffron (Affron® is clinically proven to modulate serotonin and dopamine), and magnesium (which lowers excitatory nervous activity) makes it ideal for those with high stress or anxiety related issues.

We recommend that you take REM+ each night before sleep. Since you do not need to take REM+ with food, you can take it a couple hours after dinner or right before sleeping. It’s important to note that REM+ It is not a sleeping pill—it’s a recovery supplement that improves sleep quality. Since it does not contain any sedatives or habit-forming ingredients, it will not make you feel groggy the next day. 

Unlike many sleep aids, REM+ does not disrupt your natural sleep cycles, or leave you feeling groggy the next day—or create a dependency. All ingredients are non-habit-forming and designed to restore your body’s intrinsic ability to produce calming neurotransmitters and sleep hormones. In fact, many users find that after consistent use, their sleep improves even on nights they don’t take it.